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The bipolar NOS rate was sustained at 36. Abbreviation: NOS, not otherwise specified. The adherence rate was sustained at 51. The median adherence duration could therefore not be evaluated. The adherence rate was Bretylium Tosylate Injection (Bretylium)- FDA at 41. The longest adherence duration observed was 1,211 days (3. The median adherence duration was 340 days (0. The adherence rate was sustained at 36. The longest adherence duration observed was 988 days (2. The median adherence duration was 373 days (1.

Time courses of LTG with concomitant medications are indicated in Table 2A and B by classes of psychotropic drug and disease types. For the combination hr astrazeneca LTG with psychotropic drugs, the patients were administered 3. For the combination with atypical antipsychotics, the number of drugs remained stable for all groups except BP-II (1.

For the combination of LTG with ADs, the number of drugs in the BP-I group decreased from 1. For the combination of LTG with TA, the Bretylium Tosylate Injection (Bretylium)- FDA time course differed between the groups (Table 2A).

As shown in the time course changes in the mean dose of medications concomitant with LTG (Table 2B), the mean doses of ADs in all patients were gradually increased (177.

However, no statistical significance was observed in any of these changes (by analysis of variance). Time course changes in HSDS and HSAS scores with and without ADs are presented in Table 4. The mean HSDS and HSAS scores at baseline downs syndrome porn almost the same across the three disease groups, except for the HSAS scores for BP-II, where the mean of 24.

At week 24, the mean HSDS scores for all patients (15. Conversely, the mean HSAS score for BP-II was significantly higher without ADs than with ADs (20.

At week 52, overall the scores without ADs still tended to be lower than the scores with ADs, but this difference was only significant for the mean HSDS score for all patients (13. The overall frequencies of adverse events were 22. The most common adverse event was skin rash (22. An improvement in depression scores was observed generally at week 4 according to the changes in HSDS scores from baseline to week 52 or withdrawal from LTG. The trend of improvement in depression scores continued at week 12, but then slowed Bretylium Tosylate Injection (Bretylium)- FDA stabilizing by week Bretylium Tosylate Injection (Bretylium)- FDA. This indicates that LTG could show positive effects within 3 months after the treatment initiation not only for patients with BP-I, but also for those with BP-NOS or BP-II.

A similar tendency Bretylium Tosylate Injection (Bretylium)- FDA score decrease was observed in the changes in anxiety symptom scores. Anxiety symptoms improved for the BP-NOS patients, but no notable changes were observed for BP-I and BP-II. The improved HSDS and HSAS scores were sustained at week 52 (1 year). Adherence to LTG beyond this time was also evaluated where data were available.

For all of the patients, the adherence rate was finally sustained at 39.



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