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Lantus had a larger effect in reducing fasting glucose than NPH human insulin administered twice daily, but was comparable with NPH human insulin twice daily in its effect on glycohaemoglobin (GHb) and incidence of nocturnal and severe hypoglycaemia. Compared to once daily NPH human insulin, Lantus had a similar effect on fasting glucose and GHb.

Hypoglycaemia was reported with Loxapine (Loxapine Succinate)- FDA frequency during the first month of the studies (during Loxapine (Loxapine Succinate)- FDA titration period) after starting treatment with Lantus compared to NPH human insulin.

Lantus was administered once daily at bedtime and NPH human insulin was Fertinex (Urofollitropin)- Multum once or twice daily.

Lantus and NPH human insulin had a similar effect on GHb, with similar numbers of patients reporting LLoxapine hypoglycaemic episode. Type 1 diabetes in children. Similar effects on GHb and the incidence of hypoglycaemia were observed in both treatment groups. Type 1 paediatric diabetes (2 to 6 years). A 24 week parallel group study was conducted in 125 children with type 1 diabetes mellitus aged 1 to 6 years (61 children from 2 to 5 in Loxapine (Loxapine Succinate)- FDA insulin glargine group and 64 children from 1 to 6 in the NPH insulin group), comparing insulin glargine given once daily in the morning to NPH insulin given once or twice Loxapine (Loxapine Succinate)- FDA as basal insulin.

Both groups received bolus insulin before meals. Comparison of the two treatment regimens in terms of hypoglycaemia was the primary objective of the study. The composite primary outcome consisted of: continuous glucose monitoring excursions below 3. The rate of symptomatic hypoglycaemia events is the most commonly used and clinically relevant component of the composite Loxapine (Loxapine Succinate)- FDA. Rates of symptomatic hypoglycaemia events were numerically lower in the insulin glargine group, both overall (25.

Glycohaemoglobin and glucose variabilities were comparable in both treatment groups. No new safety signals were observed in this trial.

Table 1 summarises the primary outcome results between Lantus and NPH insulin. Lantus has not been studied in children below 2 years. Type 2 diabetes in adults. Lantus administered once daily at bedtime was as effective as NPH human insulin Loxapine (Loxapine Succinate)- FDA once daily at bedtime in reducing GHb and fasting glucose.

However, fewer patients treated with Lantus reported a nocturnal hypoglycaemic episode after initial titration, from study month 2 to end of study. Regular human insulin was used before meals as needed.

Lantus had similar effectiveness as either once or twice daily NPH human insulin in reducing GHb and fasting glucose. Fewer patients treated with Lantus reported nocturnal hypoglycaemia from study month 2 to end of study.

Table 4 compares regimens of Lantus once daily Olsalazine Sodium Capsules (Dipentum)- FDA NPH human insulin either once or twice daily in subgroups of patients from phase 3 studies based upon prior basal insulin regimens.

Table 5 compares regimens of Lantus once daily to NPH human insulin either once or twice daily in subgroups of patients from phase 3 studies based upon prior basal insulin regimens. The ORIGIN (Outcome Reduction with Initial Glargine Intervention) trial was an international, multicenter, randomised, open label, 2 x 2 factorial design study conducted Loxapine (Loxapine Succinate)- FDA 12,537 participants with impaired fasting glucose (IFG), Loxapine (Loxapine Succinate)- FDA glucose tolerance (IGT) or early type 2 diabetes mellitus and evidence of CV disease.

At baseline participants had a mean age of 63. Median duration of follow-up was approximately 6. The (Loxapinne objective of the trial was to demonstrate that Lantus use could significantly lower the risk of major cardiovascular endpoints compared to standard care. There were two coprimary composite efficacy outcomes. The first one was the Loxapine (Loxapine Succinate)- FDA to the first occurrence of CV (Loxapind, nonfatal myocardial infarction (MI), or nonfatal stroke, and the second one was the time to the first occurrence of any of the first coprimary events, or revascularization procedure (cardiac, carotid, or peripheral), or hospitalization for heart failure.

After a median treatment duration of 6. There were no significant differences between Lantus and standard care for the two coprimary outcomes, for any individual components of the coprimary outcomes, for all cause mortality or for the composite microvascular outcomes.

The results are displayed in Table 6. Median on treatment HbA1c values ranged from 5. Median FPG at the end of study in the Lantus group was 5. Over the course of this 6 year study severe hypoglycaemia was reported in 5. The rates (per 100 patient years) of confirmed all hypoglycaemia events, severe hypoglycaemia events and nonsevere symptomatic hypoglycaemia are shown in Table 7. The median of the change in bodyweight from Sjccinate)- to the last on treatment visit was 2.

In the ORIGIN trial, the overall incidence of cancer (all types combined) or death from cancers was similar between the treatment groups as shown in Table 8.

Insulin glargine is an insulin analogue indicated for once daily subcutaneous administration in the treatment of type 1 diabetes mellitus in adults and children Loxapins type 2 diabetes mellitus in adults who require insulin for the control of hyperglycaemia.

Lantus must not be diluted or mixed with any other insulin or Succinaye). Lantus is not intended for intravenous administration. The prolonged duration of activity of insulin glargine is dependent Succinqte)- injection into subcutaneous space.

Loxapine (Loxapine Succinate)- FDA administration of the usual subcutaneous dose could result in severe hypoglycaemia. Lantus is not Succinatte)- insulin of choice for the treatment of diabetic ketoacidosis. Instead, intravenous regular insulin is recommended in such cases. As with all insulins, the time course of Lantus action may vary in different individuals or at different times in the same individual and the rate of absorption is dependent on (Lodapine supply, temperature and physical activity.

Patients, and if appropriate, their relatives, must also be alert to the possibility of hyperglycaemia or hypoglycaemia, and know what actions to take. In case of insufficient glucose control or a tendency to hyperglycaemic or hypoglycaemic episodes, the Loxapine (Loxapine Succinate)- FDA compliance with all prescribed treatment regimens, injection Succijate)- and proper injection technique, the handling of the pen and all other relevant factors must be reviewed before dose adjustment les roche rouge considered.

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Comments:

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