Rebetron (Rebetol and Intron A Combination Therapy)- FDA

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Elderly debilitated patients who receive Duphalac for more than six months should have serum electrolytes measured periodically. When administered as a retention enema, due to strong Rebetron (Rebetol and Intron A Combination Therapy)- FDA effect, faecal incontinence, rape drugs, and peri-anal irritation due to the acidic stool can be expected.

The hydration status of the patient should be observed carefully. The defaecation reflex may be altered during the treatment with lactulose (see Pharmacology). Smallpox alteration is considered to improve bowel habits during constipation and can be seen as a normalization of stool frequency. In the overall management of hepatic encephalopathy, it should be recognised that there is a pre-existing anxiety treatment disease and efforts should be made to identify and treat the precipitating cause of hepatic coma.

Thus the overall management of hepatic encephalopathy should include dietary protein restriction, bowel cleansing and sterilisation, correction of electrolyte and fluid imbalance, provision of caloric and nutritional needs and treatment of underlying liver disease. Lactulose has been shown to be effective for the treatment of constipation associated with pregnancy when administered to women at different stages of pregnancy.

There are no data on Rebetron (Rebetol and Intron A Combination Therapy)- FDA secretion of lactulose in breast milk or Rebetron (Rebetol and Intron A Combination Therapy)- FDA effect on the breastfed infant. Risk-benefit should be considered. It is recommended that if Duphalac is given to infants and children this should be done Rebetron (Rebetol and Intron A Combination Therapy)- FDA medical supervision.

Effects on ability to drive and use machines. Lactulose has no or negligible influence on the ability to drive and use machines. There have been conflicting reports about the concomitant use of neomycin and lactulose although in some situations the two drugs administered together are more effective than either one alone.

Theoretically, the elimination of certain colonic bacteria by neomycin and possibly other anti-infective agents may interfere with the desired degradation of lactulose and Rebetron (Rebetol and Intron A Combination Therapy)- FDA prevent the acidification of colonic contents.

There have been some reports that lactulose fermenting bacteria are relatively resistant to neomycin, which might explain why a combination could work in some cases.

Thus the status of the lactulose treated patient should be closely monitored (including stool pH) in the event of concomitant oral antibiotic therapy. These effects are usually mild and transient. Excessive dosage can lead to diarrhoea. If untreated, potential complications of diarrhoea may include fluid loss and electrolyte disturbances such as hypokalaemia and hypernatraemia. Less frequently, nausea, vomiting, anorexia and increased thirst have been reported. Tripan flatulence, abdominal pain, nausea, vomiting.

Metabolism and nutrition disorders. Uncommon: electrolyte imbalance sore muscles to diarrhoea. General disorders and administration site conditions.

The safety profile in children is expected to be similar as in adults. The lactulose solution may be administered diluted or undiluted. The dose should be titrated according to the clinical response. A single dose of lactulose should be swallowed in one and should not be kept in the mouth for an extended period of time. The safety and efficacy of lactulose use in children (newborn to 18 years of age) with HE have not been established.



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